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Obstructive Sleep Apnea (OSA) Assignment

This is a potentially serious sleep disorder. It causes breathing to repeatedly stop and start during sleep. There are several types of sleep apnea, but the most common type is obstructive sleep apnea. This condition occurs when the throat muscles intermittently relax and block the airway during sleep. A noticeable sign of obstructive sleep apnea is snoring (Foroughi, et al., 2016).

In the current case, patient might also be suffering from this disorder because she reported snoring during sleep.

At this point, it can be inferred that patient is having comorbid medical conditions including restless leg syndrome and obstructive sleep apnea. These two conditions are affecting her sleep pattern and due to lack of quality sleep she might be having depressive symptoms. Sleep problems often result in depressive problems (Luca et al., 2013)

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List two pharmacologic agents and their dosing that would be appropriate for the patient’s sleep/wake therapy based on pharmacokinetics and pharmacodynamics. From a mechanism of action perspective, provide a rationale for why you might choose one agent over the other.

The two pharmacologic agents that would be appropriate for the patient include:

  1. modafinil
  2. Mirapex

Modafinil is a wake-promoting agent approved for the treatment of excessive sleepiness associated with shift work disorder, obstructive sleep apnea (OSA) and narcolepsy (Stahl, 2014). This drug would be helpful for patient in controlling her problem of obstructive sleep apnea (OSA) that is causing her issues of snoring. The current dose of modafinil prescribed to the patient is 400 mg/day. This dose is the full dose. However, I would not prescribe full dose to the patient considering her age and possible side effects of the medicine at full dose.

Mirapex is prescribed for treatment of restless legs syndrome and Parkinson’s disease. The medicine can improve symptoms of restless legs syndrome and Parkinson’s disease and can improve sleep (Stahl, 2014). The medicine should be started at lowest dose (0.125 mg) and increased necessary every 5 to 7 days until symptoms are controlled (Stahl, 2014). Therefore, for the treatment of RLS, Mirapex would be prescribed to the patient. Obstructive Sleep Apnea (OSA) Assignment

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