DNP 810 Topic 1 DQ 1
DNP 810 Topic 1 DQ 1
DNP 810 Topic 1 DQ 1
Name three essential structural elements of a functional eukaryotic chromosome and describe their functions. Discuss the implications related to research, health, and life span in terms of one of the structural elements.
Eukaryotic Chromosome
An essential structural element of a functional eukaryotic chromosome of interest:
Introduction
The primary focus of chromosomal engineering fields is the study of systems biology, genetics, synthetic biology, and the functional analysis of genomes. Telomeres protect chromosome ends from incomplete DNA synthesis, inappropriate fusion, and degradation during DNA replication in eukaryotic cells. Telomeres and adjacent sub-telomeric regions are two types of eukaryotic chromosome ends. Telomeres protect chromosome ends from external attacks and prevent the loss of genetic information.
Telomeres are double-stranded repetitive G-rich DNA structures with Telomeres nucleoprotein structures at the
ends of eukaryotic chromosomes. The proper structure and function of telomeres are critical for the maintenance of genome integrity in order to conserve genetic information, chromosomal stability, and cell survival. Epigenetic regulators are critical in controlling the chromatin state at telomeres and sub-telomeric regions. Telomeres are maintained by cellular activities associated with telomerase and telomere binding proteins, which help yeast, animals, and plants maintain chromosomal homeostasis.
The implications of Telomeres element for research: Research studies shows that the lengths of telomeres at birth are determined by genetic makeup. Other factors such as environmental and living conditions affect the telomere lengths during an individual’s lifespan. Extreme and long-term stress has also been shown to negatively impact telomeres and their protective function and some chromosomal abnormalities in offspring are influenced by the stress experienced by parents (Konečná, K., Lyčka, M., Nohelová, L., Petráková, M., Fňašková, M., Koriťáková, E., Sováková, P., P., Brabencová, S., Preiss, M., Rektor, I., Fajkus, J., Fojtová, M., 2019).
The implications of Telomeres element on health: The previous assumption shows that aging is a primary risk factor for neurodegenerative disease (ND), especially in Alzheimer’s and Parkinson’s patients. Leukocyte telomere length (LTL) serves as a predictor of neurological disease because the Telomeres ribonucleoprotein complexes that cap eukaryotic chromosomes shorten in leukocytes with aging (Konečná, et al., 2019).
The implications of Telomeres element for life span: telomeres are most rapidly shortened during the first four years of life and the rate of telomere shortening differs with age. in humans, the telomere length at birth is determined mostly by genetics, environmental conditions, gender, and maternal stress during pregnancy. Modifiable factors that can affect Telomeres include low socioeconomic factors, and lifestyle status including obesity, cigarette smoking, and stress. Exposure to severe and long-lasting stress conditions is associated with shorter telomere length and notable symptoms of premature aging persisted after the stress subsided (Konečná, et al., 2019).
How can the doctoral-prepared nurse apply this information in practice? Explain.
Currently, I work with elderly demented patients and the study of eukaryotic chromosome with a focus on Tolemeres have shed light on some causes of Alzheimer’s and Parkinson’s patients. Knowledge gained from this topic shows that individual personality which is difficult to express is a crucial factor in the capability of each person to cope with extremely stressful conditions. Resilient individuals with distinct personal qualities such as optimism, positive affect, self-efficacy, and high self-esteem are relevant parameters to survive post-traumatic stress symptoms Lee, W., K., & Cho, M., H., 2019).