DNP 810 Full Course Discussions GCU Tasks
DNP 810 Full Course Discussions GCU Tasks
DNP 810 Full Course Discussions GCU Tasks
The relationship between drug concentration and effect causes pharmacodynamic variability. In either case, these specific genealogical variants mediating drug concentrations or their concomitant outcomes are increasingly being recognized as sources of variable drug action — ‘pharmacogenetics’ (Lin, 2007). One source of genetic variation is mutations, which are changes in the sequences of genes in DNA (Lin, 2007). Gene flow, or the movement of genes between different groups of organisms, is another source (Lin, 2007). Finally, sexual reproduction can cause genetic variation, resulting in the creation of new gene combinations (Lin, 2007). When it comes to drug responses, different populations are impacted when it comes to polymorphisms in the genealogical scape, especially when it comes to ethnic vulnerability to adverse drug reactions. The frequency of genetic variation varies by ethnicity, which may be related to differences in susceptibility to adverse drug reactions among different populations. Variation in response to equivalent drug concentrations results from a variety of factors, including differences in receptor number and structure, receptor-coupling mechanisms, and physiological changes in target organs caused by genetic, age, and health differences (Lin, 2007).
Variations in drug response may be pharmacodynamic, implying inter-individual differences in the response of
receptors in equal concentrations of the drug. In addition, it may also be pharmacokinetic, indicating that individuals receiving the same drug dose will have different drug concentrations in their body fluids (Hartmanshenn et al., 2016). Moreover, both inheritance and acquisition of either instance of variance are sure to follow. Variations in receptor sensitivity occur, but few inherited or acquired instances have well-documented clinical relevance. Should the therapeutic index reside at a decreased level or the causal relationship of the response as well as dosage does not retain a level of steepness, the concentration within the specific drug of the receptor region will not be critical, and causes of kinetic variation are unlikely to be clinically significant (Hartmanshenn et al., 2016). However, it is the many causes of kinetic variation, including effects due to drug formulation and changes in the absorption, distribution, metabolism, and excretion of drugs (Hartmanshenn et al., 2016). Analyzing and predicting variability due to these factors is desirable if consideration of dynamics suggests drug concentration will determine therapeutic efficacy.
References
Hartmanshenn, C., Scherholz, M., & Androulakis, I. P. (2016). Physiologically-based pharmacokinetic models: approaches for enabling personalized medicine. Journal of pharmacokinetics and pharmacodynamics, 43(5), 481-504.
Lin, J. H. (2007). Pharmacokinetic and pharmacodynamic variability: a daunting challenge in drug therapy. Current drug metabolism, 8(2), 109-136.
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Thanks, Ms. Jennifer for your interesting post.
In addition, research studies conducted by Wjdan et al., have enhanced the knowledge about the physiology and biochemistry of some genetic disorders. They combined molecular techniques and classical biochemical methods to improve the detection and help in developing advanced strategies to treat patients with genetic health conditions (Wjdan, et al., 2021). Depending on the methods implemented, the outcomes must be correlated with the clinical picture and genetic variants identified by studying family history critically.
DNP-prepared nurses must be knowledgeable enough on drawbacks associated with the diagnostic approaches of genetic testing to prevent a false-negative diagnosis, validate borderline cases, and detect unusual and novel variants. Advancements in technology produced different portable and rapid devices including platforms-based immune assay, density-based separation, and sensor-based technologies to diagnose certain genetic diseases (Wjdan, et al., 2021).
DNP 810 Topic 1 DQ 1
Choose a news story, within last two years, about genetic or genomic technology. What is the issue presented? From the perspective of an RN or APRN, what are the ethical, cultural, religious, legal, fiscal, and societal implications of the issue? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 1 DQ 2
Identify a specific disease encountered in your clinical practice or personal life. Can your patient’s understanding of DNA/RNA replication, transcription, and translation affect the management of the disease? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 2 DQ 1
Identify a complex inheritance health issue you encountered in your clinical practice or personal life. How would you approach working with a patient of a complex inheritance health issue? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 2 DQ 2
Refer to the complex inheritance health issue identified in DQ 1. Given available genetic tests, which would you use to screen and diagnose this issue? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 3 DQ 1
A multi-generational family health history can facilitate your management of a patient’s disease. What model would you use to create a multi-generational family health history for a patient? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 3 DQ 2
Why is it important to have a comprehensive health and physical assessment that includes information on environment and genomic influences? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 4 DQ 1
In the past decade there have been many advances in genetics and genomics and their application to health screening, diagnosis, treatment, and prognosis. What recent advancement do you believe is the most significant for your clinical practice? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 4 DQ 2
Genetic/genomic factors are known to contribute to variability of pharmacologic responses in some patients. How does the variability of responses result in tailoring pharmacologic agents to the care of these patients? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 5 DQ 1
Health issues in a clinical setting can be influenced by nutrition. Identify a health issue that has been positively influenced by nutrition in your clinic. How does nutrition improve health? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 5 DQ 2
Choose one disorder of malnutrition that is found in your clinical setting or community. What are the genetic and environmental influences on this disorder, including prevalence rates, testing, treatment, and prognosis? How can the doctoral-prepared nurse apply this information into practice? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 6 DQ 1
What is the impact of the aging population on both increased health care expenditures and wasted resources? Do genetics play a role? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 6 DQ 2
Identify a method that uses evidence-based data to support new or innovative ways to care for the aging population. What are the anticipated outcomes of employing this method and methods like it? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 7 DQ 1
What is the impact of chronic disease on both increased health care expenditures and wasted resources? Do genetics play a role? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 7 DQ 2
Identify a method that uses evidence-based data to support new or innovative ways to care for patients with chronic disease. What are the anticipated outcomes of employing this method and methods like it? How can the doctoral-prepared nurse apply this information in practice? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 8 DQ 1
Choose a news story, within last two years, about genetic or genomic technology. What is the issue presented? From the perspective of an RN or APRN, what are the ethical, cultural, religious, legal, fiscal, and societal implications of the issue? Explain. Support your rationale with a minimum of two scholarly sources.
DNP 810 Topic 8 DQ 2
There are several issues that undermine client rights to make genetic and genomic-related decisions and act. Identify two issues you have seen undermine these rights in your clinical setting. What are potential solutions for each? What is your role as the patient advocate with each issue? Explain. Support your rationale with a minimum of two scholarly sources.